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New publication in Nature Communications

Metabolic phenotypic data of 2016 knockout mouse strains were analyzed!

Out of 2016 knockout strains 974 with strong metabolic phenotypes were found, of which 429 had no previous link to metabolism and 51 genes remain functionally completely unannotated. The human orthologues of 23 murine candidate genes are associated with metabolic disease as revealed by published genome wide association studies. Further bioinformatic analyses of gene regulatory elements unraveled an extensive metabolic phenotype-associated network of co-regulated genes. 

See manuscript here