Persönlicher Status und Werkzeuge

Sprachwahl

Publikationen

2017

 

Schommers P, Thurau A, Bultmann-Mellin I, Guschlbauer M, Klatt AR, Rozman J, Klingenspor M, de Angelis MH, Alber J, Gründemann D, Sterner-Kock A, Wiesner RJ.
Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state.
Mol Metab. May 5;6(7):737-747. doi: 10.1016/j.molmet.2017.05.002. eCollection 2017 Jul., 2017 PubMed

Garrett L, Becker L, Rozman J, Puk O, Stoeger T, Yildirim AÖ, Bohla A, Eickelberg O, Hans W, Prehn C, Adamski J, Klopstock T, Rácz I, Zimmer A, Klingenspor M, Fuchs H, Gailus-Durner V, Wurst W, Hrabě de Angelis M, Graw J, Hölter SM.
Fgf9 Y162C Mutation Alters Information Processing and Social Memory in Mice.
Mol Neurobiol.Jul 10. doi: 10.1007/s12035-017-0659-3. [Epub ahead of print], 2017 PubMed

Salminen AV, Garrett L, Schormair B, Rozman J, Giesert F, Niedermeier KM, Becker L, Rathkolb B, Rácz I; German Mouse Clinic Consortium, Klingenspor M, Klopstock T, Wolf E, Zimmer A, Gailus-Durner V, Torres M, Fuchs H, de Angelis MH, Wurst W, Hölter SM, Winkelmann J.
Meis1 effects on motor phenotypes and the sensorimotor system in mice.
Dis Model Mech.Jun 23. pii: dmm.030080. doi: 10.1242/dmm.030080. [Epub ahead of print], 2017 PubMed

Bolze F, Mocek S, Zimmermann A, Klingenspor M.
Aminoglycosides, but not PTC124 (Ataluren), rescue nonsense mutations in the leptin receptor and in luciferase reporter genes.
Sci Rep. Apr 21;7(1):1020. doi: 10.1038/s41598-017-01093-9, 2017 PubMed

Ryan DP, Henzel KS, Pearson BL, Siwek ME, Papazoglou A, Guo L, Paesler K, Yu M, Müller R, Xie K, Schröder S, Becker L, Garrett L, Hölter SM, Neff F, Rácz I, Rathkolb B, Rozman J, Ehninger G, Klingenspor M, Klopstock T, Wolf E, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Sidiropoulou K, Weiergräber M, Zhou Y, Ehninger D.
A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice.
Mol Psychiatry. Apr 4. doi: 10.1038/mp.2017.53. [Epub ahead of print], 2017 PubMed

Gimpfl M, Rozman J, Dahlhoff M, Kübeck R, Blutke A, Rathkolb B, Klingenspor M, Hrabě de Angelis M, Öner-Sieben S, Seibt A, Roscher AA, Wolf E, Ensenauer R.
Modification of the fatty acid composition of an obesogenic diet improves the maternal and placental metabolic environment in obese pregnant mice.
Biochim Biophys Acta.Jun;1863(6):1605-1614. doi: 10.1016/j.bbadis.2017.02.021. Epub Feb 21, 2017 PubMed

Kless C, Rink N, Rozman J, Klingenspor M.
Proximate causes for diet-induced obesity in laboratory mice: a case study.
Eur J Clin Nutr. Mar;71(3):306-317. doi: 10.1038/ejcn.2016.243. Epub Feb 1. Review., 2017 PubMed

Gerngroß C, Schretter J, Klingenspor M, Schwaiger M, Fromme T.
Active Brown Fat During 18F-FDG PET/CT Imaging Defines a Patient Group with Characteristic Traits and an Increased Probability of Brown Fat Redetection.
J Nucl Med.Jul;58(7):1104-1110. doi: 10.2967/jnumed.116.183988. Epub Jan 19., 2017 PubMed

Tews D, Fromme T, Keuper M, Hofmann SM, Debatin KM, Klingenspor M, Wabitsch M, Fischer-Posovszky P.Teneurin-2 (TENM2) deficiency induces UCP1 expression in differentiating human fat cells.
Mol Cell Endocrinol.Mar 5;443:106-113. doi: 10.1016/j.mce.2017.01.015. Jan 11., 2017 PubMed

 

2016


Barquissau V, Ghandour RA, Ailhaud G, Klingenspor M, Langin D, Amri EZ, Pisani DF.
Control of adipogenesis by oxylipins, GPCRs and PPARs.
Biochimie.Dec 27. pii: S0300-9084(16)30317-0. doi: 10.1016/j.biochi.2016.12.012. [Epub ahead of print] Review, 2016 PubMed

Li Y, Fromme T, Klingenspor M.
Meaningful respirometric measurements of UCP1-mediated thermogenesis.
Biochimie.Dec 14. pii: S0300-9084(16)30320-0. doi: 10.1016/j.biochi.2016.12.005. [Epub ahead of print], 2016 PubMed

Zimprich A, Mroz G, Meyer Zu Reckendorf C, Anastasiadou S, Förstner P, Garrett L, Hölter SM, Becker L, Rozman J, Prehn C, Rathkolb B, Moreth K, Wurst W, Klopstock T, Klingenspor M, Adamski J, Wolf E, Bekeredjian R, Fuchs H, Gailus-Durner V, de Angelis MH, Knöll B.
Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms.
Mol Neurobiol. [Epub ahead of print], Dec 2, 2016 PubMed

Kübeck R, Bonet-Ripoll C, Hoffmann C, Walker A, Müller VM, Schüppel VL, Lagkouvardos I, Scholz B, Engel KH, Daniel H, Schmitt-Kopplin P, Haller D, Clavel T, Klingenspor M.
Dietary fat and gut microbiota interactions determine diet-induced obesity in mice.
Mol Metab. Oct 13;5(12):1162-1174, 2016 PubMed

Fuchs H, Sabrautzki S, Przemeck GK, Leuchtenberger S, Lorenz-Depiereux B, Becker L, Rathkolb B, Horsch M, Garrett L, Östereicher MA, Hans W, Abe K, Sagawa N, Rozman J, Vargas-Panesso IL, Sandholzer M, Lisse TS, Adler T, Aguilar-Pimentel JA, Calzada-Wack J, Ehrhard N, Elvert R, Gau C, Hölter SM, Micklich K, Moreth K, Prehn C, Puk O, Racz I, Stoeger C, Vernaleken A, Michel D, Diener S, Wieland T, Adamski J, Bekeredjian R, Busch DH, Favor J, Graw J, Klingenspor M, Lengger C, Maier H, Neff F, Ollert M, Stoeger T, Yildirim AÖ, Strom TM, Zimmer A, Wolf E, Wurst W, Klopstock T, Beckers J, Gailus-Durner V, Hrabě de Angelis M.
The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.
G3 (Bethesda).Nov 4. pii: g3.116.033670. doi: 10.1534/g3.116.033670. [Epub ahead of print], 2016 PubMed

Berger E, Rath E, Yuan D, Waldschmitt N, Khaloian S, Allgäuer M, Staszewski O, Lobner EM, Schöttl T, Giesbertz P, Coleman OI, Prinz M, Weber A, Gerhard M, Klingenspor M, Janssen KP, Heikenwalder M, Haller D.
Mitochondrial function controls intestinal epithelial stemness and proliferation.
Nat Commun.Oct 27;7:13171. doi: 10.1038/ncomms13171, 2016 PubMed

Lohr K, Pachl F, Moghaddas Gholami A, Geillinger KE, Daniel H, Kuster B, Klingenspor M.
Reduced mitochondrial mass and function add to age-related susceptibility toward diet-induced fatty liver in C57BL/6J mice.
Physiol Rep.Oct;4(19). pii: e12988, 2016 PubMed

Sabrautzki S, Sandholzer MA, Lorenz-Depiereux B, Brommage R, Przemeck G, Vargas Panesso IL, Vernaleken A, Garrett L, Baron K, Yildirim AO, Rozman J, Rathkolb B, Gau C, Hans W, Hoelter SM, Marschall S, Stoeger C, Becker L, Fuchs H, Gailus-Durner V, Klingenspor M, Klopstock T, Lengger C, Stefanie L, Wolf E, Strom TM, Wurst W, de Angelis MH.
Viable Ednra Y129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation.
Mamm Genome.Dec;27(11-12):587-598, 2016 PubMed

Bolze F, Bast A, Mocek S, Morath V, Yuan D, Rink N, Schlapschy M, Zimmermann A, Heikenwalder M, Skerra A, Klingenspor M.
Treatment of diet-induced lipodystrophic C57BL/6J mice with long-acting PASylated leptin normalises insulin sensitivity and hepatic steatosis by promoting lipid utilisation.
Diabetologia.Sep;59(9):2005-12. doi: 10.1007/s00125-016-4004-6, 2016 PubMed

Kumar S, Rathkolb B, Kemter E, Sabrautzki S, Michel D, Adler T, Becker L, Beckers J, Busch DH, Garrett L, Hans W, Hölter SM, Horsch M, Klingenspor M, Klopstock T, Rácz I, Rozman J, Vargas Panesso IL, Vernaleken A, Zimmer A, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Wolf E, Aigner B.
Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice.
PLoS One. Mar 22;11(3):e0150472. doi: 10.1371/journal.pone.0150472. eCollection 2016 PubMed

Kistler M, Muntean A, Szymczak W, Rink N, Fuchs H, Gailus-Durner V, Wurst W, Hoeschen C, Klingenspor M, Hrabě de Angelis M, Rozman J.
Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice.
J Breath Res. Feb 10;10(1):016009. doi: 10.1088/1752-7155/10/1/016009, 2016 PubMed

Korner G, Scherer T, Adamsen D, Rebuffat A, Crabtree M, Rassi A, Scavelli R, Homma D, Ledermann B, Konrad D, Ichinose H, Wolfrum C, Horsch M, Rathkolb B, Klingenspor M, Beckers J, Wolf E, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Blau N, Rozman J, Thöny B.J Inherit Metab 
Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice.
Dis. Mar;39(2):309-19. doi: 10.1007/s10545-015-9909-6. Epub 2016 Feb 1,2016 PubMed

 

2015

Maurer SF, Fromme T, Grossman LI, Hüttemann M, Klingenspor M.
The brown and brite adipocyte marker Cox7a1 is not required for non-shivering thermogenesis in mice.
Sci Rep.Dec 4;5:17704. doi: 10.1038/srep17704, 2015 download

Bolze F, Morath V, Bast A, Rink N, Schlapschy M, Mocek S, Skerra A, Klingenspor M.
Long-acting PASylated leptin ameliorates obesity by promoting satiety and preventing hypometabolism in leptin-deficient Lepob/ob mice.
Endocrinology. Oct 22;en20151519, 2015 download

Schöttl T, Kappler L, Fromme T, Klingenspor M.
Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status.
Mol Metab 4, 631-642, 2015 download

de Angelis MH, Nicholson G, Selloum M, White JK, Morgan H, Ramirez-Solis R, Sorg T, Wells S, Fuchs H, Fray M, Adams DJ, Adams NC, Adler T, Aguilar-Pimentel A, Ali-Hadji D, Amann G, André P, Atkins S, Auburtin A, Ayadi A, Becker J, Becker L, Bedu E, Bekeredjian R, Birling MC, Blake A, Bottomley J, Bowl MR, Brault V, Busch DH, Bussell JN, Calzada-Wack J, Cater H, Champy MF, Charles P, Chevalier C, Chiani F, Codner GF, Combe R, Cox R, Dalloneau E, Dierich A, Di Fenza A, Doe B, Duchon A, Eickelberg O, Esapa CT, Fertak LE, Feigel T, Emelyanova I, Estabel J, Favor J, Flenniken A, Gambadoro A, Garrett L, Gates H, Gerdin AK, Gkoutos G, Greenaway S, Glasl L, Goetz P, Da Cruz IG, Götz A, Graw J, Guimond A, Hans W, Hicks G, Hölter SM, Höfler H, Hancock JM, Hoehndorf R, Hough T, Houghton R, Hurt A, Ivandic B, Jacobs H, Jacquot S, Jones N, Karp NA, Katus HA, Kitchen S, Klein-Rodewald T, Klingenspor M, Klopstock T, Lalanne V, Leblanc S, Lengger C, le Marchand E, Ludwig T, Lux A, McKerlie C, Maier H, Mandel JL, Marschall S, Mark M, Melvin DG, Meziane H, Micklich K, Mittelhauser C, Monassier L, Moulaert D, Muller S, Naton B, Neff F, Nolan PM, Nutter LM, Ollert M, Pavlovic G, Pellegata NS, Peter E, Petit-Demoulière B, Pickard A, Podrini C, Potter P, Pouilly L, Puk O, Richardson D, Rousseau S, Quintanilla-Fend L, Quwailid MM, Racz I, Rathkolb B, Riet F, Rossant J, Roux M, Rozman J, Ryder E, Salisbury J, Santos L, Schäble KH, Schiller E, Schrewe A, Schulz H, Steinkamp R, Simon M, Stewart M, Stöger C, Stöger T, Sun M, Sunter D, Teboul L, Tilly I, Tocchini-Valentini GP, Tost M, Treise I, Vasseur L, Velot E, Vogt-Weisenhorn D, Wagner C, Walling A, Wattenhofer-Donze M, Weber B, Wendling O, Westerberg H, Willershäuser M, Wolf E, Wolter A, Wood J, Wurst W, Yildirim AÖ, Zeh R, Zimmer A, Zimprich A; EUMODIC Consortium, Holmes C, Steel KP, Herault Y, Gailus-Durner V, Mallon AM, Brown SD.
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
Nat Genet. Jul 27, 2015 [Epub ahead of print] PubMed

Deng T, Zhu ZI, Zhang S, Postnikov Y, Huang D, Horrsch M, Furusawa T, Beckers J, Rozman J, Klingenspor M, Amarie O, Graw J, Rathkolb B, Wolf E, Adler T, Busch DH, Galius-Durner V, Fuchs H, Hrabe de Angelis M, van der Velde A, Tessarollo L, Ovcherenko I, Landsman D, Bustin M.
Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers.
Genome Res.Jul 8, 2015 [Epub ahead of print] PubMed

Fischer B, Schöttl T, Schempp C, Fromme T, Hauner H, Klingenspor M, Skurk T.
Inverse relationship between body mass index and mitochondrial oxidative phosphorylation capacity in human subcutaneous adipocytes.
Am J Physiol Endocrinol Metab. Jun 16, 2015 [Epub ahead of print] PubMed


Morath V, Bolze F, Schlapschy M, Schneider S, Sedlmayer F, Seyfarth K, Klingenspor M, Skerra A.
PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhanced in Vivo Efficacy.
Mol Pharm. May 4;12(5):1431-42, 2015 PubMed


Kless C, Müller VM, Schüppel VL, Lichtenegger M, Rychlik M, Daniel H, Klingenspor M, Haller D.
Diet-induced obesity causes metabolic impairment independent of alterations in gut barrier integrity.
Mol Nutr Food Res. May;59(5):968-78, 2015 PubMed

Rozman J, Rathkolb B, Neschen S, Fuchs H, Gailus-Durner V, Klingenspor M, Wolf E, Hrabě de Angelis M.
Glucose tolerance tests for systematic screening of glucose homeostasis in mice.
Curr Protoc Mouse Biol. Mar 2;5(1):65-84, 2015 PubMed

Schöttl T, Kappler L, Braun K, Fromme T, Klingenspor M.
Limited mitochondrial capacity of visceral versus subcutaneous white adipocytes in male C57BL/6N mice.
Endocrinology. Mar;156(3):923-33, 2015 PubMed

Keeney JG, O'Bleness MS, Anderson N, Davis JM, Arevalo N, Busquet N, Chick W, Rozman J, Hölter SM, Garrett L, Horsch M; German Mouse Clinic Consortium, Beckers J, Wurst W, Klingenspor M, Restrepo D, de Angelis MH, Sikela JM. Generation of mice lacking DUF1220 protein domains: effects on fecundity and hyperactivity.
Mamm Genome. Feb;26(1-2):33-42, 2015 PubMed

Seyfarth K, Poschmann G, Rozman J, Fromme T, Rink N, Hofmann A, Wurst W, Stühler K, Klingenspor M.
The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice.
J Nutr Biochem. Jan;26(1):75-81, 2015 PubMed
 

2014

Walker A, Pfitzner B, Neschen S, Kahle M, Harir M, Lucio M, Moritz F, Tziotis D, Witting M, Rothballer M, Engel M, Schmid M, Endesfelder D, Klingenspor M, Rattei T, Castell WZ, de Angelis MH, Hartmann A, Schmitt-Kopplin P.
Distinct signatures of host-microbial meta-metabolome and gut microbiome in two C57BL/6 strains under high-fat diet.
ISME J. Dec;8(12):2380-96. 2014 PubMed

Li Y, Fromme T, Schweizer S, Schöttl T, Klingenspor M.
Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes.
EMBO Rep. Oct;15(10):1069-76, 2014 PubMed

Rozman J, Klingenspor M, Hrabě de Angelis M.
A review of standardized metabolic phenotyping of animal models.
Mamm Genome. Oct;25(9-10):497-507, 2014 Pubmed
Li Y, Bolze F, Fromme T, Klingenspor M.
Intrinsic differences in BRITE adipogenesis of primary adipocytes from two different mouse strains.
Biochim Biophys Acta. Sep;1841(9):1345-52, 2014 PubMed

Tews D, Schwar V, Scheithauer M, Weber T, Fromme T, Klingenspor M, Barth TF, Möller P, Holzmann K, Debatin KM, Fischer-Posovszky P, Wabitsch M.
Comparative gene array analysis of progenitor cells from human paired deep neck and subcutaneous adipose tissue.
Mol Cell Endocrinol. Sep;395(1-2):41-50, 2014 PubMed

Lang R, Fromme T, Beusch A, Lang T, Klingenspor M, Hofmann T.
Raw coffee based dietary supplements contain carboxyatractyligenin derivatives inhibiting mitochondrial adenine-nucleotide-translocase.
Food Chem Toxicol. Aug;70:198-204, 2014 PubMed

Li Y, Lasar D, Fromme T, Klingenspor M. White, brite, and brown adipocytes: the evolution and function of a heater organ in mammals.Canadian Journal of Zoology July; 92(7): 615-626. 2014 go to journal website

Poschmann G, Seyfarth K, Besong Agbo D, Klafki HW, Rozman J, Wurst W, Wiltfang J, Meyer HE, Klingenspor M, Stühler K.
High-fat diet induced isoform changes of the Parkinson's disease protein DJ-1.
J Proteome Res. May 2;13(5):2339-51, 2014 PubMed

Stribl C, Samara A, Trümbach D, Peis R, Neumann M, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Rathkolb B, Wolf E, Beckers J, Horsch M, Neff F, Kremmer E, Koob S, Reichert AS, Hans W, Rozman J, Klingenspor M, Aichler M, Walch AK, Becker L, Klopstock T, Glasl L, Hölter SM, Wurst W, Floss T.
Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.
J Biol Chem. Apr 11;289(15):10769-84, 2014 Pubmed
Spieler D, Kaffe M, Knauf F, Bessa J, Tena JJ, Giesert F, Schormair B, Tilch E, Lee H, Horsch M, Czamara D, Karbalai N, von Toerne C, Waldenberger M, Gieger C, Lichtner P, Claussnitzer M, Naumann R, Müller-Myhsok B, Torres M, Garrett L, Rozman J, Klingenspor M, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Beckers J, Hölter SM, Meitinger T, Hauck SM, Laumen H, Wurst W, Casares F, Gómez-Skarmeta JL, Winkelmann J.
Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon.
Genome Res. Apr;24(4):592-603, 2014 PubMed
Kistler M, Szymczak W, Fedrigo M, Fiamoncini J, Höllriegl V, Hoeschen C, Klingenspor M, Hrabě de Angelis M, Rozman J.
Effects of diet-matrix on volatile organic compounds in breath in diet-induced obese mice. 
J Breath Res. Mar;8(1):016004, 2014 PubMed
Kraus P, V S, Yu HB, Xing X, Lim SL, Adler T, Pimentel JA, Becker L, Bohla A, Garrett L, Hans W, Hölter SM, Janas E, Moreth K, Prehn C, Puk O, Rathkolb B, Rozman J, Adamski J, Bekeredjian R, Busch DH, Graw J, Klingenspor M, Klopstock T, Neff F, Ollert M, Stoeger T, Yildrim AÖ, Eickelberg O, Wolf E, Wurst W, Fuchs H, Gailus-Durner V, de Angelis MH, Lufkin T, Stanton LW.
Pleiotropic functions for transcription factor zscan10.
PLoS One. Aug 11;9(8):e104568, 2014. Pubmed
Knoll N, Jarick I, Volckmar AL, Klingenspor M, Illig T, Grallert H, Gieger C, Wichmann HE, Peters A, Wiegand S, Biebermann H, Fischer-Posovszky P, Wabitsch M, Völzke H, Nauck M, Teumer A, Rosskopf D, Rimmbach C, Schreiber S, Jacobs G, Lieb W, Franke A, Hebebrand J, Hinney A.
Mitochondrial DNA variants in obesity.
PLoS One. May 2;9(5):e94882, 2014 Pubmed

Claussnitzer M, Dankel SN, Klocke B, Grallert H, Glunk V, Berulava T, Lee H, Oskolkov N, Fadista J, Ehlers K, Wahl S, Hoffmann C, Qian K, Rönn T, Riess H, Müller-Nurasyid M, Bretschneider N, Schroeder T, Skurk T, Horsthemke B; DIAGRAM+Consortium, Spieler D, Klingenspor M,Seifert M, Kern MJ, Mejhert N, Dahlman I,Hansson O, Hauck SM, Blüher M, Arner P, Groop L, Illig T, Suhre K,Hsu YH, Mellgren G, Hauner H, Laumen H.
Leveraging cross-species transcription factor binding site patterns: from diabetes risk Loci to disease mechanisms.
Cell. Jan 16;156(1-2):343-58, 2014 PubMed

2013

Hoffmann C, Zimmermann A, Hinney A, Volckmar AL, Jarrett HW, Fromme T, Klingenspor M.
A Novel SP1/SP3 Dependent Intronic Enhancer Governing Transcription of the UCP3 Gene in Brown Adipocytes.
PLoS One. Dec 31;8(12):e83426, 2013 PubMed

Hölter SM, Stromberg M, Kovalenko M, Garrett L, Glasl L, Lopez E, Guide J, Götz A, Hans W, Becker L, Rathkolb B, Rozman J, Schrewed A, Klingenspor M, Klopstock T, Schulz H, Wolf E, Wursta W, Gillis T, Wakimoto H, Seidman J, MacDonald ME, Cotman S, Gailus-Durner V, Fuchs H, de Angelis MH, Lee JM, Wheeler VC.
A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice.
PLoS One. Nov 22;8(11):e80923, 2013 PubMed 

Szymczak W, Rozman J, Höllriegl V, Kistler M, Keller S, Peters D, Kneipp M, Schulz H, Hoeschen C, Klingenspor M, Hrabě de Angelis M.
Online breath gas analysis in unrestrained mice by hs-PTR-MS.
Mamm Genome. Apr;25(3-4):129-40, 2013 PubMed 

Dahlhoff M, Pfister S, Blutke A, Rozman J, Klingenspor M, Deutsch MJ, Rathkolb B, Fink B, Gimpfl M, Hrabě de Angelis M, Roscher AA, Wolf E, Ensenauer R.
Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring.
Biochim Biophys Acta. Feb;1842(2):304-17, 2013 PubMed

Kemter E, Prückl P, Rathkolb B, Micklich K, Adler T, Becker L, Beckers J, Busch DH, Götz AA, Hans W, Horsch M, Ivandic B, Klingenspor M, Klopstock T, Rozman J, Schrewe A, Schulz H, Fuchs H, Gailus-Durner V, Hrabé de Angelis M, Wolf E, Aigner B.
Standardized, Systemic Phenotypic Analysis of Umod (C93F) and Umod (A227T) Mutant Mice.
PLoS One. Oct 24;8(10):e78337, 2013 PubMed

Besong Agbo D, Klafki H, Poschmann G, Seyfarth K, Genius J, Janßen C, Stühler K, Wurst W, Meyer HE, Klingenspor M, Wiltfang J.
Development of a capillary isoelectric focusing immunoassay to measure DJ-1 isoforms in biological samples.
Anal Biochem. Dec 15;443(2):197-204, 2013 PubMed

Schöttl T, Klingenspor M.
Boosting mitochondrial biogenesis in white adipocytes: A route towards improved insulin sensitivity?
Mol Metab. Jul 10;2(3):128-9, 2013 PubMed

Gruber L, Kisling S, Lichti P, Martin FP, May S, Klingenspor M, Lichtenegger M, Rychlik M, Haller D.
High fat diet accelerates pathogenesis of murine Crohn's disease-like ileitis independently of obesity.
PLoS One. Aug 16;8(8):e71661, 2013 Pubmed

Neff F, Flores-Dominguez D, Ryan DP, Horsch M, Schröder S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Garrett L, Hans W, Hettich MM, Holtmeier R, Hölter SM, Moreth K, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Naton B, Ordemann R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Ehninger G, Graw J, Höfler H, Klingenspor M, Klopstock T, Ollert M, Stypmann J, Wolf E, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Ehninger D.
Rapamycin extends murine lifespan but has limited effects on aging.
J Clin Invest. Aug;123(8):3272-91, 2013 Pubmed

Tews D, Fischer-Posovszky P, Fromme T, Klingenspor M, Fischer J, Rüther U, Marienfeld R, Barth T, Möller P, Debatin K, Wabitsch M.
FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes
Endocrinology. Sep;154(9):3141-51, 2013 Pubmed

Geiser F, Klingenspor M, McAllan BM.
A functional nexus between photoperiod acclimation, torpor expression and somatic fatty acid composition in a heterothermic mammal.
PLoS One. May 22;8(5):e63803, 2013 Pubmed

Lang R, Fromme T, Beusch A, Wahl A, Klingenspor M, Hofmann T.
2-O-β-d-Glucopyranosyl-carboxyatractyligenin from Coffea L. inhibits adenine nucleotide translocase in isolated mitochondria but is quantitatively degraded during coffee roasting.
Phytochemistry. Sep;93:124-35, 2013 Pubmed

Nordström V, Willershäuser M, Herzer S, Rozman J, von Bohlen Und Halbach O, Meldner S, Rothermel U, Kaden S, Roth FC, Waldeck C, Gretz N, de Angelis MH, Draguhn A, Klingenspor M, Gröne HJ, Jennemann R.
Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.
PLoS Biol.
11(3):e1001506, 2013 Pubmed

Ju L, Wing J, Taylor E, Brandt R, Slijepcevic P, Horsch M, Rathkolb B, Rácz I, Becker L, Hans W, Adler T, Beckers J, Rozman J, Klingenspor M, Wolf E, Zimmer A, Klopstock T, Busch DH, Gailus-Durner V, Fuchs H, de Angelis MH, van der Horst G, Lehmann AR.
SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities.
DNA Repair (Amst).May 1;12(5):356-66, 2013 Pubmed

Knoll N, Jarick I, Volckmar AL, Klingenspor M, Illig T, Grallert H, Gieger C, Wichmann HE, Peters A, Hebebrand J, Scherag A, Hinney A.
Gene set of nuclear-encoded mitochondrial regulators is enriched for common inherited variation in obesity.
PLoS One.Feb;8(2):e55884, 2013. Pubmed

Lasar D, Julius A, Fromme T, Klingenspor M.
Browning attenuates murine white adipose tissue expansion during postnatal development.
Biochim Biophys Acta (BBA) - Molecular and Cell Biology of Lipids. Jan;30: S1388-1981, 2013 Pubmed

Helwig M, Herwig A, Heldmaier G, Barrett P, Mercer JG, Klingenspor M.
Photoperiod-dependent regulation of carboxypeptidase E affects selective processing of neuropeptides in the seasonal Siberian hamster (Phodopus sungorus).
J Neuroendocrinol. Feb;25(2):190-7, 2013 Pubmed

 

 

2012

Volckmar AL, Bolze F, Jarick I, Knoll N, Scherag A, Reinehr T, Illig T, Grallert H, Wichmann HE, Wiegand S, Biebermann H, Krude H, Fischer-Posovszky P, Rief W, Wabitsch M, Klingenspor M, Hebebrand J, Hinney A.
Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants.
BMC Med Genomics.2012 Dec 27. Pubmed

Klingenspor M, Herzig S, Pfeifer A.
Brown Fat Develops a Brite Future.
Obes Facts. Dec 22;5(6):890-896, 2012 Pubmed

Hochrath K, Krawczyk M, Goebel R, Langhirt M, Rathkolb B, Micklich K, Rozman J, Horsch M, Beckers J, Klingenspor M, Fuchs H, Gailus-Durner V, Wolf E, Acalovschi M, Volmer DA, Hrabe de Angelis M, Lammert F.
The hepatic phosphatidylcholine transporter ABCB4 as modulator of glucose homeostasis.
FASEB J. Dec;26(12):5081-91, 2012 Pubmed

Helwig M, Herwig A, Heldmaier G, Barrett P, Mercer JG, Klingenspor M.
Photoperiod-dependent regulation of carboxypeptidase E affects selective processing of neuropeptides in the seasonal Siberian hamster (Phodopus sungorus).
J Neuroendocrinol. Feb;25(2):190-7, 2012 Pubmed

Fuchs H, Gailus-Durner V, Neschen S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Bohla A, Calzada-Wack J, Cohrs C, Dewert A, Fridrich B, Garrett L, Glasl L, Götz A, Hans W, Hölter SM, Horsch M, Hurt A, Janas E, Janik D, Kahle M, Kistler M, Klein-Rodewald T, Lengger C, Ludwig T, Maier H, Marschall S, Micklich K, Möller G, Naton B, Prehn C, Puk O, Rácz I, Räß M, Rathkolb B, Rozman J, Scheerer M, Schiller E, Schrewe A, Steinkamp R, Stöger C, Sun M, Szymczak W, Treise I, Vargas Panesso IL, Vernaleken AM, Willershäuser M, Wolff-Muscate A, Zeh R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Eickelberg O, Favor J, Graw J, Höfler H, Höschen C, Katus H, Klingenspor M, Klopstock T, Neff F, Ollert M, Schulz H, Stöger T, Wolf E, Wurst W, Yildirim AO, Zimmer A, Hrabě de Angelis M.
Innovations in phenotyping of mouse models in the German Mouse Clinic.
Mamm Genome. Oct;23(9-10):611-22, 2012. Pubmed

Desmarchelier C, Ludwig T, Scheundel R, Rink N, Bader BL, Klingenspor M, Daniel H.
Diet-induced obesity in ad libitum-fed mice: food texture overrides the effect of macronutrient composition.
Br J Nutr. Aug 6:1-10, 2012. Pubmed

Lee AW, Hengstler H, Schwald K, Berriel-Diaz M, Loreth D, Kirsch M, Kretz O, Haas CA, de Angelis MH, Herzig S, Brümmendorf T, Klingenspor M, Rathjen FG, Rozman J, Nicholson G, Cox RD, Schäfer MK.
Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype.
PLoS One. 7(7):e41537, 2012. Pubmed

Fuchs H, Sabrautzki S, Seedorf H, Rathkolb B, Rozman J, Hans W, Schneider R, Klaften M, Hölter SM, Becker L, Klempt M, Elvert R, Wurst W, Klopstock T, Klingenspor M, Wolf E, Gailus-Durner V, de Angelis MH.
Does enamelin have pleiotropic effects on organs other than the teeth? Lessons from a phenotyping screen of two enamelin-mutant mouse lines.
Eur J Oral Sci. Aug;120(4):269-77, 2012. Pubmed

Hüttemann M, Lee I, Gao X, Pecina P, Pecinova A, Liu J, Aras S, Sommer N, Sanderson TH, Tost M, Neff F, Aguilar-Pimentel JA, Becker L, Naton B, Rathkolb B, Rozman J, Favor J, Hans W, Prehn C, Puk O, Schrewe A, Sun M, Höfler H, Adamski J, Bekeredjian R, Graw J, Adler T, Busch DH, Klingenspor M, Klopstock T, Ollert M, Wolf E, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Weissmann N, Doan JW, Bassett DJ, Grossman LI.
Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology.
FASEB J. Sep;26(9):3916-30, 2012. Pubmed

Irmler M, Gentier RJ, Dennissen FJ, Schulz H, Bolle I, Hölter SM, Kallnik M, Cheng JJ, Klingenspor M, Rozman J, Ehrhardt N, Hermes DJ, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Meyer HE, Hopkins DA, Van Leeuwen FW, Beckers J.
Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients.
Acta Neuropathol. Aug;124(2):187-97, 2012. Pubmed

Staropoli JF, Haliw L, Biswas S, Garrett L, Hölter SM, Becker L, Skosyrski S, Da Silva-Buttkus P, Calzada-Wack J, Neff F, Rathkolb B, Rozman J, Schrewe A, Adler T, Puk O, Sun M, Favor J, Racz I, Bekeredjian R, Busch DH, Graw J, Klingenspor M, Klopstock T, Wolf E, Wurst W, Zimmer A, Lopez E, Harati H, Hill E, Krause DS, Guide J, Dragileva E, Gale E, Wheeler VC, Boustany RM, Brown DE, Breton S, Ruether K, Gailus-Durner V, Fuchs H, de Angelis MH, Cotman SL.
Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system.
PLoS One. 7(6):e38310, 2012. Pubmed

Klingenspor M, Fromme, T
Brown Adipose Tissue. pp39-69, 2012
In: Adipose Tissue Biology; edited by Symonds MEE; Springer New York Link

Jastroch M, Hirschberg V, Klingenspor M
Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak.
Biochim Biophys Acta Sep;1817(9):1660-70, 2012. Pubmed

Olszewski PK, Rozman J, Jacobsson JA, Rathkolb B, Strömberg S, Hans W, Klockars A, Alsiö A, Risérus U, Becker L, Hölter SM, Elvert R, Ehrhardt N, Gailus-Durner V, Fuchs H, Fredriksson R, Wolf E, Klopstock T, Wurst W, Levine AS, Marcus C, Hrabé de Angelis M, Klingenspor M, Schiöth HB, Kilimann MW.Neurobeachin, a Regulator of Synaptic Protein Targeting, Is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-Mass Index in Humans.
PLoS Genet 8(3): e1002568, 2012. open access

Tups A, Stöhr S, Helwig M, Barrett P, Krol E, Schachtner J, Mercer JG, Klingenspor M.
Seasonal leptin resistance is associated with impaired signalling via JAK2-STAT3 but not ERK, possibly mediated by reduced hypothalamic GRB2 protein.
J Comp Physiol B May;182(4):553-67, 2012 Pubmed

Grünz G, Haas K, Soukup S, Klingenspor M, Kulling SE, Daniel H, Spanier B.
Structural features and bioavailability of four flavonoids and their implications for lifespan-extending and antioxidant actions in C. elegans.
Mech Ageing Dev. Jan;133(1):1-10, 2012 Pubmed

2011

Baur P, Martin FP, Gruber L, Bosco N, Brahmbhatt V, Collino S, Guy P, Montoliu I, Rozman J, Klingenspor M, Tavazzi I, Thorimbert A, Rezzi S, Kochhar S, Benyacoub J, Kollias G, Haller D.
Metabolic phenotyping of the Crohn's Disease-like IBD etiopathology in the TNF(ΔARE/WT) mouse model.
J Proteome Res. Dec 2;10(12):5523-35, 2011 Pubmed

Hirschberg V ,Fromme T, Klingenspor M.
Test systems to study the structure and function of uncoupling protein 1: a critical overview.
Frontiers in Endocrinology 2, 2011 free online access

Bolze F, Rink N, Brumm H, Kühn R, Mocek S, Schwarz AE, Kless C, Biebermann H, Wurst W, Rozman J, Klingenspor M.
Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo.
Pharmacogenomics J 2011 Oct 4. doi: 10.1038/tpj.2011.43. [Epub ahead of print]

Gotz AA, Rozman J, Rodel HG, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Klingenspor M, Stoeger T.
Comparison of particle-exposure triggered pulmonary and systemic inflammation in mice fed with three different diets.
Part Fibre Toxicol Sep 27;8(1):30, 2011. [Pubmed]

Raab M, Kappel S, Krämer A, Sanhaji M, Matthess Y, Kurunci-Csacsko E, Calzada-Wack J, Rathkolb B, Rozman J, Adler T, Busch DH, Esposito I, Fuchs H, Gailus-Durner V, Klingenspor M, Wolf E, Sänger N, Prinz F, Angelis MH, Seibler J, Yuan J, Bergmann M, Knecht R, Kreft B, Strebhardt K.
Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells.
Nat Commun Jul 19;2:395, 2011. Pubmed

Brumm H, Mühlhaus J, Bolze F, Scherag S, Hinney A, Hebebrand J, Wiegand S, Klingenspor M, Grüters A, Krude H, Biebermann H.
Rescue of Melanocortin 4 Receptor (MC4R) Nonsense Mutations by Aminoglycoside-Mediated Read-Through.
Obesity (Silver Spring). Jul 7, 2011. Pubmed

Polymeropoulos ET, Heldmaier G, Frappell PB, McAllan BM, Withers KW, Klingenspor M, White CR, Jastroch M.
Phylogenetic differences of mammalian basal metabolic rate are not explained by mitochondrial basal proton leak.
Proc Biol Sci Jun 1, 2011. Pubmed

Horsch M, Seeburg PH, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Garrett L, Götz A, Hans W, Higuchi M, Hölter SM, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Schrewe A, Adamski J, Busch DH, Esposito I, Graw J, Ivandic B, Klingenspor M, Klopstock T, Mempel M, Ollert M, Schulz H, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, de Angelis MH, Beckers J.
Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice.
J Biol Chem 286(21):18614-22, 2011. Pubmed

Abe K, Fuchs H, Boersma A, Hans W, Yu P, Kalaydjiev S, Klaften M, Adler T, Calzada-Wack J, Mossbrugger I, Rathkolb B, Rozman J, Prehn C, Maraslioglu M, Kametani Y, Shimada S, Adamski J, Busch DH, Esposito I, Klingenspor M, Wolf E, Wurst W, Gailus-Durner V, Katan M, Marschall S, Soewarto D, Wagner S, de Angelis MH.
A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model.
Arthritis Rheum 63(5):1301-11, 2011. Pubmed

Fromme T and Klingenspor M.
Uncoupling protein 1 expression and high fat diets.
Am J Physiol Regul Integr Comp Physiol 300(1):R1-8, 2011. Pubmed, free PDF

Fuchs H, Durner VG, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Da Silva-Buttkus P, Neff F, Götz A, Hans W, Hölter SM, Horsch M, Kastenmüller G, Kemter E, Lengger C, Maier H, Matloka M, Möller G, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Römisch-Margl W, Rozman J, Wang-Sattler R, Schrewe A, Stöger C, Tost M, Adamski J, Aigner B, Beckers J, Behrendt H, Busch DH, Esposito I, Graw J, Illig T, Ivandic B, Klingenspor M, Klopstock T, Kremmer E, Mempe M, Neschen S, Ollert M, Schulz H, Suhre K, Wolf E, Wurst W, Zimmer A, Hrabě de Angelis M.
Mouse phenotyping.
Methods 53:120-135, 2011. Pubmed

2010

Meyer CW, Willershäuser M, Jastroch M, Rourke B, Fromme T, Oelkrug R, Heldmaier G, Klingenspor M.
Adaptive thermogenesis and thermal conductance in wildtype and UCP1-KO mice.
Am J Physiol Regul Integr Comp Physiol 299(5):R1396-406, 2010. Pubmed

Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, de Angelis MH, Dikic I.
CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice.
EMBO J. 29(14):2421-32, 2010. Pubmed

Vegiopoulos A, Müller-Decker K, Strzoda D, Schmitt I, Chichelnitskiy E, Ostertag A, Berriel Diaz M, Rozman J, Hrabe de Angelis M, Nüsing RM, Meyer CW, Wahli W, Klingenspor M, Herzig S.
Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes.
Science 328(5982):1158-61, 2010. Pubmed

Scherag A, Dina C, Hinney A, Vatin V, Scherag S, Vogel CI, Müller TD, Grallert H, Wichmann HE, Balkau B, Heude B, Jarvelin MR, Hartikainen AL, Levy-Marchal C, Weill J, Delplanque J, Körner A, Kiess W, Kovacs P, Rayner NW, Prokopenko I, McCarthy MI, Schäfer H, Jarick I, Boeing H, Fisher E, Reinehr T, Heinrich J, Rzehak P, Berdel D, Borte M, Biebermann H, Krude H, Rosskopf D, Rimmbach C, Rief W, Fromme T, Klingenspor M, Schürmann A, Schulz N, Nöthen MM, Mühleisen TW, Erbel R, Jöckel KH, Moebus S, Boes T, Illig T, Froguel P, Hebebrand J, Meyre D.
Two new loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.
PLoS Genet 6(4):e1000916, 2010. Pubmed

Hesse D, Dunn M, Heldmaier G, Klingenspor M, Rozman J.
Behavioural mechanisms affecting energy regulation in mice prone or resistant to diet- induced obesity.
Physiol Behav 99(3): 370-380, 2010. Pubmed

Tocchetti A, Soppo CB, Zani F, Bianchi F, Gagliani MC, Pozzi B, Rozman J, Elvert R, Ehrhardt N, Rathkolb B, Moerth C, Horsch M, Fuchs H, Gailus-Durner V, Beckers J, Klingenspor M, Wolf E, Hrabé de Angelis M, Scanziani E, Tacchetti C, Scita G, Di Fiore PP, Offenhäuser N.
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.
PLoS One 5(3):e9468, 2010. Pubmed

Rosemann M, Ivashkevich A, Favor J, Dalke C, Hölter SM, Becker L, Rácz I, Bolle I, Klempt M, Rathkolb B, Kalaydjiev S, Adler T, Aguilar A, Hans W, Horsch M, Rozman J, Calzada-Wack J, Kunder S, Naton B, Gailus-Durner V, Fuchs H, Schulz H, Beckers J, Busch DH, Burbach JP, Smidt MP, Quintanilla-Martinez L, Esposito I, Klopstock T, Klingenspor M, Ollert M, Wolf E, Wurst W, Zimmer A, Hrabé de Angelis M, Atkinson M, Heinzmann U, Graw J.
Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice.
Mamm Genome 21(1-2):13-27, 2010. Pubmed

Morgan H, Beck T, Blake A, Gates H, Adams N, Debouzy G, Leblanc S, Lengger C, Maier H, Melvin D, Meziane H, Richardson D, Wells S, White J, Wood J; EUMODIC Consortium, de Angelis MH, Brown SD, Hancock JM, Mallon AM.
EuroPhenome: a repository for high-throughput mouse phenotyping data.
Nucleic Acids Res 38(Database issue):D577-85, 2010. Pubmed

 

2009

Forner F, Kumar C, Luber CA, Fromme T, Klingenspor M, Mann M.
Proteome differences between brown and white fat mitochondria reveal specialized metabolic functions.
Cell Metab 10(4):324-35, 2009. Pubmed

Singmann P, Baumert J, Herder C, Meisinger C, Holzapfel C, Klopp N, Wichmann HE, Klingenspor M, Rathmann W, Illig T, Grallert H.
Gene-Gene Interaction between APOA5 and USF1: Two Candidate Genes for the Metabolic Syndrome.
Obesity Facts 2(4): 235-242, 2009. free download

Kemter E, Rathkolb B, Rozman J, Hans W, Schrewe A, Landbrecht C, Klaften M, Ivandic BT, Fuchs H Noyes, Gailus-Durner V, Klingenspor M, Hrabe de Angelis M, Wolf E, Wanke R, Aigner B.
Novel Missense Mutation of Uromodulin in Mice Causes Renal Dysfunction with Alterations in Urea Handling, Energy and Bone Metabolism.
Am J Physiol Renal Physiol 297(5): F1391-8. 2009. Pubmed

Jastroch M, Withers KW, Stoehr S, Klingenspor M.
Mitochondrial Proton Conductance in Skeletal Muscle of a Cold-Exposed Marsupial, Antechinus flavipes, Is Unlikely to Be Involved in Adaptive Nonshivering Thermogenesis but Displays Increased Sensitivity toward Carbon-Centered Radicals.
Physiol Biochem Zool 82(5):447-54. 2009. Pubmed

Rubio-Aliaga I, Przemeck GK, Fuchs H, Gailus-Durner V, Adler T, Hans W, Horsch M, Rathkolb B, Rozman J, Schrewe A, Wagner S, Hoelter SM, Becker L, Klopstock T, Wurst W, Wolf E, Klingenspor M, Ivandic BT, Busch DH, Beckers J, Hrabé de Angelis M.
Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.
PLoS One 4(6):e6054, 2009. Pubmed

Enard W, Gehre S, Hammerschmidt K, Hölter SM, Blass T, Somel M, Brückner MK, Schreiweis C, Winter C, Sohr R, Becker L, Wiebe V, Nickel B, Giger T, Müller U, Groszer M, Adler T, Aguilar A, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Favor J, Fuchs H, Gailus-Durner V, Hans W, Hölzlwimmer G, Javaheri A, Kalaydjiev S, Kallnik M, Kling E, Kunder S, Moßbrugger I, Naton B, Racz I, Rathkolb B, Rozman J, Schrewe A, Busch DH, Graw J, Ivandic B, Klingenspor M, Klopstock T, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, Zimmer A, Fisher SE, Morgenstern R, Arendt T, Hrabé de Angelis M, Fischer J, Schwarz J, Päabo S.
A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice.
Cell 137, 961–971, 2009. Journal home page

Meyer CW, Wagener A, Rink N, Hantschel C, Heldmaier G, Klingenspor M, Brockmann GA.
High Energy Digestion Efficiency and Altered Lipid Metabolism Contribute to Obesity in BFMI Mice.
Obesity 17(11):1988-93, 2009. Pubmed

Fromme T, Hoffmann C, Nau K, Rozman J, Reichwald K, Utting M, Platzer M, Klingenspor M.
An intronic single base exchange leads to a brown adipose tissue specific loss of Ucp3 expression and an altered body mass trajectory.
Physiol Genomics 38(1):54-62, 2009. Pubmed

Helwig M, Archer ZA, Heldmaier G, Tups A, Mercer JG, Klingenspor M.
Photoperiodic regulation of satiety mediating neuropeptides in the brainstem of the seasonal Siberian hamster (Phodopus sungorus).
J Comp Physiol A Neuroethol Sens Neural Behav Physiol
195(7):631-42, 2009. Pubmed

Bolze F, Klingenspor M.
Mouse models for the central melanocortin system.
Genes Nutr 4(2):129-34, 2009. Pubmed

Gailus-Durner V, Fuchs H, Adler T, Aguilar Pimentel A, Becker L, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Ferwagner B, Hans W, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Mörth C, Mossbrugger I, Naton B, Prehn C, Puk O, Rathkolb B, Rozman J, Schrewe A, Thiele F, Adamski J, Aigner B, Behrendt H, Busch DH, Favor J, Graw J, Heldmaier G, Ivandic B, Katus H, Klingenspor M, Elisabeth Kremmer TK, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, de Angelis MH.
Systemic First-Line Phenotyping.
Methods Mol Biol 530:1-47, 2009. Pubmed

Khasawneh J, Schulz MD, Walch A, Rozman J, Hrabe de Angelis M, Klingenspor M, Buck A, Schwaiger M, Saur D, Schmid RM, Klöppel G, Sipos B, Greten FR, Arkan MC.
Inflammation and mitochondrial fatty acid β-oxidation link obesity to early tumor promotion.
Proc Natl Acad Sci USA 106(9):3354-9, 2009. Pubmed

Fuchs H, Gailus-Durner V, Adler T, Pimentel JA, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Dalke C, Ehrhardt N, Fasnacht N, Ferwagner B, Frischmann U, Hans W, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Maier H, Moßbrugger I, Mörth C, Naton B, Nöth U, Pasche B, Prehn C, Przemeck G, Puk O, Racz I, Rathkolb B, Rozman J, Schäble K, Schreiner R, Schrewe A, Sina C, Steinkamp R, Thiele F, Willershäuser M, Zeh R, Adamski J, Busch DH, Beckers J, Behrendt H, Daniel H, Esposito I, Favor J, Graw J, Heldmaier G, Höfler H, Ivandic B, Katus H, Klingenspor M, Klopstock T, Lengeling A, Mempel M, Müller W, Neschen S, Ollert M, Quintanilla-Martinez L, Rosenstiel P, Schmidt J, Schreiber S, Schughart K, Schulz H, Wolf E, Wurst W, Zimmer A, de Angelis MH.
The German Mouse Clinic: A Platform for Systemic Phenotype Analysis of Mouse Models.
Curr Pharm Biotechnol 10(2):236-243, 2009. Pubmed

Hughes DA, Jastroch M, Stoneking M, Klingenspor M.
Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis.
BMC Evol Biol 7(9):4, 2009. Open Access

2008

Jastroch M, Klingenspor M. A new look at the evolution of uncoupling protein 1-mediated non-shivering thermogenesis. In: Hypometabolism in Animals: Hibernation, torpor and cryobiology . Lovegrove BG, McKechnie AE, editors. Pietermaritzburg: Interpak Books; p 197-208, 2008.

Mzilikazi N, Meyer CW, Klingenspor M. Towards ecological relevance: a comparison of physiological and molecular evidence for the presence of adaptive, UCP1-mediated non-shivering thermogenesis in mammals. In: Hypometabolism in Animals: Hibernation, torpor and cryobiology. Lovegrove BG, McKechnie AE, editors. Pietermaritzburg: Interpak Books; p 209-14, 2008.

Diaz MB, Krones-Herzig A, Metzger D, Ziegler A, Vegiopoulos A, Klingenspor M, Müller-Decker K, Herzig S. Nuclear receptor cofactor receptor interacting protein 140 controls hepatic triglyceride metabolism during wasting in mice. Hepatology 48(3):782-91, 2008. Pubmed

Trzcionka M, Withers KW, Klingenspor M, Jastroch M. The effects of fasting and cold exposure on metabolic rate and mitochondrial proton leak in liver and skeletal muscle of an amphibian, the cane toad Bufo marinus. J Exp Biol 211(Pt 12):1911-8, 2008. Pubmed

Khorooshi R, Helwig M, Werckenthin A, Steinberg N, Klingenspor M. Seasonal regulation of cocaine- and amphetamine-regulated transcript in the arcuate nucleus of Djungarian hamster (Phodopus sungorus). Gen Comp Endocrinol 157(2):142-7, 2008. Pubmed

Klingenspor M, Fromme T, Hughes DA Jr, Manzke L, Polymeropoulos E, Riemann T, Trzcionka M, Hirschberg V, Jastroch M. An ancient look at UCP1. Biochim Biophys Acta 1777(7-8): 637-41 2008. Pubmed

Jastroch M, Withers KW, Taudien S, Frappell PB, Helwig M, Fromme T, Hirschberg V, Heldmaier G, McAllan BM, Firth BT, Burmester T, Platzer M, Klingenspor M. Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis. Physiol Genomics 32(2):161-9, 2008. Pubmed

Nau K, Fromme T, Meyer CW, von Praun C, Heldmaier G, Klingenspor M. Brown adipose tissue specific lack of uncoupling protein 3 is associated with reduced cold tolerance and global reduction of metabolic gene expression. J Comp Physiol [B] 178(3):269-77, 2008. Pubmed

Braulke LJ, Klingenspor M, Debarber A, Tobias SC, Grandy DK, Scanlan TS, Heldmaier G. 3-Iodothyronamine: a novel hormone controlling the balance between glucose and lipid utilisation. J Comp Physiol [B] 178(2):167-77, 2008. Pubmed

2007

Fromme T and Klingenspor M. Rapid single step subcloning procedure by combined action of type II and type IIs endonucleases with ligase. Journal of Biological Engineering 1:7, 2007 Open Access

Mzilikazi N, Jastroch M, Meyer CW, Klingenspor M. The molecular and biochemical basis of non-shivering thermogenesis in an African endemic mammal, Elephantulus myurus. Am J Physiol Regul Integr Comp Physiol 293(5):R2120-7, 2007. Pubmed

Jastroch M, Buckingham JA, Helwig M, Klingenspor M, Brand MD. Functional characterisation of UCP1 in the common carp: uncoupling activity in liver mitochondria and cold-induced expression in the brain. J Comp Physiol [B] 177(7):743-52, 2007. Pubmed

Fromme T, Reichwald K, Platzer M, Li XS, Klingenspor M. Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus sungorus. BMC Mol Biol 8:1, 2007. Pubmed

Meyer CW, Neubronner J, Rozman J, Stumm G, Osanger A, Stoeger C, Augustin M, Grosse J, Klingenspor M, Heldmaier G. Expanding the body mass range: associations between BMR and tissue morphology in wild type and mutant dwarf mice (David mice). J Comp Physiol [B] 177(2):183-92, 2007. Pubmed

Meyer CW, Elvert R, Scherag A, Ehrhardt N, Gailus-Durner V, Fuchs H, Schafer H, Hrabe de AM, Heldmaier G, Klingenspor M. Power matters in closing the phenotyping gap. Naturwissenschaften 94(5):401-6, 2007. Pubmed

Scherbarth F, Rozman J, Klingenspor M, Brabant G, Steinlechner S. Wheel running affects seasonal acclimatization of physiological and morphological traits in the Djungarian hamster (Phodopus sungorus). Am J Physiol Regul Integr Comp Physiol. 293(3):R1368-75, 2007. Pubmed

Wuertz S, Nitsche A, Jastroch M, Gessner J, Klingenspor M, Kirschbaum F, Kloas W . The role of the IGF-I system for vitellogenesis in maturing female sterlet, Acipenser ruthenus Linnaeus, 1758. Gen Comp Endocrinol 150(1):140-50, 2007. Pubmed

2006

Haemmerle G, Lass A, Zimmermann R, Gorkiewicz G, Meyer C, Rozman J, Heldmaier G, Maier R, Theussl C, Eder S, Kratky D, Wagner EF, Klingenspor M, Hoefler G, Zechner R. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312: 734-737, 2006 Pubmed

Helwig M, Khorooshi RM, Tups A, Barrett P, Archer ZA, Exner C, Rozman J, Braulke LJ, Mercer JG, Klingenspor M. PC1/3 and PC2 Gene Expression and Post-Translational Endoproteolytic Pro-Opiomelanocortin Processing is Regulated by Photoperiod in the Seasonal Siberian Hamster (Phodopus sungorus). J Neuroendocrinol 18: 413-425, 2006 Pubmed

Tups A, Helwig M, Stohr S, Barrett P, Mercer JG, Klingenspor M. Photoperiodic regulation of insulin receptor mRNA and intracellular insulin signaling in the arcuate nucleus of the Siberian hamster, Phodopus sungorus. Am J Physiol Regul Integr Comp Physiol , 2006 Pubmed

Tups A, Barrett P, Ross AW, Morgan PJ, Klingenspor M, Mercer JG. The suppressor of cytokine signalling 3, SOCS3, may be one critical modulator of seasonal body weight changes in the Siberian hamster, Phodopus sungorus. J Neuroendocrinol 18: 139-145, 2006 Pubmed

2005

Gailus-Durner V, Fuchs H, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Elvert R, Ehrhardt N, Dalke C, Franz TJ, Grundner-Culemann E, Hammelbacher S, Holter SM, Holzlwimmer G, Horsch M, Javaheri A, Kalaydjiev SV, Klempt M, Kling E, Kunder S, Lengger C, Lisse T, Mijalski T, Naton B, Pedersen V, Prehn C, Przemeck G, Racz I, Reinhard C, Reitmeir P, Schneider I, Schrewe A, Steinkamp R, Zybill C, Adamski J, Beckers J, Behrendt H, Favor J, Graw J, Heldmaier G, Hofler H, Ivandic B, Katus H, Kirchhof P, Klingenspor M, Klopstock T, Lengeling A, Muller W, Ohl F, Ollert M, Quintanilla-Martinez L, Schmidt J, Schulz H, Wolf E, Wurst W, Zimmer A, Busch DH, De Angelis MH. Introducing the German Mouse Clinic: open access platform for standardized phenotyping. Nat Methods 2: 403-404, 2005 Pubmed

Jastroch M, Wuertz S, Kloas W, Klingenspor M. Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis. Physiol Genomics 22: 150-156, 2005 Pubmed

Kanzleiter T, Schneider T, Walter I, Bolze F, Eickhorst C, Heldmaier G, Klaus S, Klingenspor M. Evidence for NR4A1 as a cold-induced effector of brown fat thermogenesis. Physiol Genomics 24(1):37-44, 2005 Pubmed

Khorooshi RM, Klingenspor M. Neuronal distribution of melanin-concentrating hormone, cocaine- and amphetamine-regulated transcript and orexin B in the brain of the Djungarian hamster (Phodopus sungorus). J Chem Neuroanat 29: 137-148, 2005 Pubmed

Schuhmann B, Dietrich A, Sel S, Hahn C, Klingenspor M, Lommatzsch M, Gudermann T, Braun A, Renz H, Nockher WA. A role for brain-derived neurotrophic factor in B cell development. J Neuroimmunol 163: 15-23, 2005 Pubmed

2004

Berriel-Diaz M, Lange M, Heldmaier G, Klingenspor M. Depression of transcription and translation during daily torpor in the Djungarian hamster (Phodopus sungorus). J Comp Physiol [B] 174: 495-502, 2004 Pubmed

Jastroch M, Withers K, Klingenspor M. Uncoupling protein 2 and 3 in marsupials: identification, phylogeny, and gene expression in response to cold and fasting in Antechinus flavipes. Physiol Genomics 17: 130-139, 2004 Pubmed

Liebig M, von Praun C, Heldmaier G, Klingenspor M. Absence of UCP3 in brown adipose tissue does not impair nonshivering thermogenesis. Physiol Biochem Zool 77: 116-126, 2004 Pubmed

Meyer CW, Korthaus D, Jagla W, Cornali E, Grosse J, Fuchs H, Klingenspor M, Roemheld S, Tschöp M, Heldmaier G, De Angelis MH, Nehls M. A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity. Endocrinology 145: 2531-2541, 2004 Pubmed

Meyer CW, Klingenspor M, Rozman J, Heldmaier G. Gene or size: metabolic rate and body temperature in obese growth hormone-deficient dwarf mice. Obes Res 12: 1509-1518, 2004 Pubmed

Tups A, Helwig M, Khorooshi RM, Archer ZA, Klingenspor M, Mercer JG. Circulating ghrelin levels and central ghrelin receptor expression are elevated in response to food deprivation in a seasonal mammal ( Phodopus sungorus). J Neuroendocrinol 16: 922-928, 2004 Pubmed

Tups A, Ellis C, Moar KM, Logie TJ, Adam CL, Mercer JG, Klingenspor M. Photoperiodic regulation of leptin sensitivity in the Siberian hamster, Phodopus sungorus, is reflected in arcuate nucleus SOCS-3 (suppressor of cytokine signaling) gene expression. Endocrinology 145: 1185-1193, 2004 Pubmed

2003

Archer ZA, Rayner DV, Rozman J, Klingenspor M, Mercer JG. Normal distribution of body weight gain in male sprague-dawley rats fed a high-energy diet. Obes Res 11: 1376-1383, 2003 Pubmed

Hebebrand J, Exner C, Hebebrand K, Holtkamp C, Casper RC, Remschmidt H, Herpertz-Dahlmann B, Klingenspor M. Hyperactivity in patients with anorexia nervosa and in semistarved rats: evidence for a pivotal role of hypoleptinemia. Physiol Behav 79: 25-37, 2003 Pubmed

Klingenspor M. Cold-induced recruitment of brown adipose tissue thermogenesis. Exp Physiol 88: 141-148, 2003 Pubmed

 

Weitere Publikationen ...

Rousseau K, Atcha Z, Cagampang FR, Le Rouzic P, Stirland JA, Ivanov TR, Ebling FJ, Klingenspor M, Loudon AS. Photoperiodic regulation of leptin resistance in the seasonally breeding Siberian hamster (Phodopus sungorus). Endocrinology 143: 3083-3095, 2002 Pubmed

Weber K, Bruck P, Mikes Z, Kupper JH, Klingenspor M, Wiesner RJ. Glucocorticoid hormone stimulates mitochondrial biogenesis specifically in skeletal muscle. Endocrinology 143: 177-184, 2002 Pubmed

Boeuf S, Klingenspor M, Van Hal NL, Schneider T, Keijer J, Klaus S. 2001. Differential gene expression in white and brown preadipocytes. Physiol Genomics 7(1):15-25.

von Praun C, Burkert M, Gessner M, Klingenspor M. 2001. Tissue-specific expression and cold-induced mRNA levels of uncoupling proteins in the Djungarian hamster. Physiol Biochem Zool 74(2):203-11.

Atcha Z, Cagampang FR, Stirland JA, Morris ID, Brooks AN, Ebling FJ, Klingenspor M, Loudon AS. 2000. Leptin acts on metabolism in a photoperiod-dependent manner, but has no effect on reproductive function in the seasonally breeding Siberian hamster (Phodopus sungorus). Endocrinology 141(11):4128-35.

Exner C, Hebebrand J, Remschmidt H, Wewetzer C, Ziegler A, Herpertz S, Schweiger U, Blum WF, Preibisch G, Heldmaier G, Klingenspor M. 2000. Leptin suppresses semi-starvation induced hyperactivity in rats: implications for anorexia nervosa. Mol Psychiatry 5(5):476-81.

Klingenspor M, Niggemann H, Heldmaier G. 2000. Modulation of leptin sensitivity by short photoperiod acclimation in the Djungarian hamster, Phodopus sungorus. J Comp Physiol [B] 170(1):37-43.

Kronfeld-Schor N, Haim A, Dayan T, Zisapel N, Klingenspor M, Heldmaier G. 2000. Seasonal thermogenic acclimation of diurnally and nocturnally active desert spiny mice. Physiol Biochem Zool 73(1):37-44.

Heldmaier G, Klingenspor M, Werneyer M, Lampi BJ, Brooks SP, Storey KB. 1999. Metabolic adjustments during daily torpor in the Djungarian hamster. Am J Physiol 276(5 Pt 1):E896-E906.

Klingenspor M, Xu P, Cohen RD, Welch C, Reue K. 1999. Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics. J Biol Chem 274(33):23078-84.

Klingenspor M, Bodnar J, Welch C, Xia YR, Lusis AJ, Reue K. 1997. Localization of ubiquitin gene family members to mouse chromosomes 5, 11, and 18. Mamm Genome 8(10):789-90.

Klingenspor M, Bodnar J, Xia YR, Welch C, Lusis AJ, Reue K. 1997. Localization of profilin-1 (Pfn1) and a related sequence (Pfn1-rs) to mouse chromosomes 11 and 15 respectively. Mamm Genome 8(7):539-40.

Kuusela P, Jacobsson A, Klingenspor M, Rehnmark S, Heldmaier G, Cannon B, Nedergaard J. 1997. Contrasting adrenergic effects on lipoprotein lipase gene expression in the brown adipose tissue of intact mice and in cultured brown adipocytes from mice. Biochim Biophys Acta 1345(3):327-37.

Klingenspor M, Dickopp A, Heldmaier G, Klaus S. 1996. Short photoperiod reduces leptin gene expression in white and brown adipose tissue of Djungarian hamsters. FEBS Lett 399(3):290-4.

Klingenspor M, Ivemeyer M, Wiesinger H, Haas K, Heldmaier G, Wiesner RJ. 1996. Biogenesis of thermogenic mitochondria in brown adipose tissue of Djungarian hamsters during cold adaptation. Biochem J 316 ( Pt 2):607-13.

Klingenspor M, Ebbinghaus C, Hulshorst G, Stohr S, Spiegelhalter F, Haas K, Heldmaier G. 1996. Multiple regulatory steps are involved in the control of lipoprotein lipase activity in brown adipose tissue. J Lipid Res 37(8):1685-95.

Meierfrankenfeld B, Abelenda M, Jauker H, Klingenspor M, Kershaw EE, Chua SC, Jr., Leibel RL, Schmidt I. 1996. Perinatal energy stores and excessive fat deposition in genetically obese (fa/fa) rats. Am J Physiol 270(4 Pt 1):E700-E708.

Klingenspor M, Meywirth A, Stohr S, Heldmaier G. 1994. Effect of unilateral surgical denervation of brown adipose tissue on uncoupling protein mRNA level and cytochrom-c-oxidase activity in the Djungarian hamster. J Comp Physiol [B] 163(8):664-70.

Bartsch C, Bartsch H, Buchberger A, Stieglitz A, Klingenspor M and Heldmaier G. Serial transplants of DMBA-induced mammary tumours in Fischer rats as model system for human breast cancer II.Analsysis of pineal melatonin biosynthesis and secretion. Advances Pin Res 30: 479-484, 1994.

Ruf TP, Klingenspor M, Preis H and Heldmaier G. Daily torpor in the Djungarian hamster (Phodopus sungorus): interactions with food intake, activity, and social behaviour. J Comp Physiol [B] 160: 609-615, 1991.

Heldmaier G, Steinlechner S, Ruf T, Wiesinger H, Klingenspor M. 1989. Photoperiod and thermoregulation in vertebrates: body temperature rhythms and thermogenic acclimation. J Biol Rhythms 4(2):251-65.

Klingenspor M, Klaus S, Wiesinger H, Heldmaier G. 1989. Short photoperiod and cold activate brown fat lipoprotein lipase in the Djungarian hamster. Am J Physiol 257(5 Pt 2):R1123-R1127.